Figure 5
Transfer of regulatory T cells (Treg cells) cannot cure established arthritis. Pre-activated CD4+CD25+ cells (1 Ă— 106) were transferred on (a) day 1 or (b) day 7 of antigen-induced arthritis (AIA). Arthritis severity was monitored by measurement of knee joint swelling and by histological assessment 14 days after cell transfer (n = 6–7 per group). (c) Also, 1 Ă— 106 pre-activated αEβ7-expressing Treg cells have no curative effect in AIA (n = 8 per group).