Phenotypic and functional characterisation of CCR7+ and CCR7- CD4+memory T cells homing to the joints in juvenile idiopathic arthritis

Table 3 Distribution of chemokine receptors of synovial tissues from patients with juvenile idiopathic arthritis

Patient no.	Age (year)	Form	Pattern	CD3	CCR7			CXCR3			CCR5
					Lining	Sublining	Aggregates	Lining	Sublining	Aggregates	Lining	Sublining	Aggregates
1	14	Oligo per.	Diffuse	+++	+	+++	NP	+++	+++	NP	+++	++	NP
2	19	Poly RF-	Diffuse	+	-	++	NP	+	+++	NP	+	-	NP
3	10	Oligo per.	T-B	++	-	+	++	+	++	++	++	+	-
4	12	Oligo ext.	T-B	+++	++	+++	+++	++	+++	+++	++	+	++
5	7	Poly RF-	T-B	++	-	-	+	++	+++	+++	+++	+	+
6	15	Poly RF-	GC	+++	-	+	++	+++	+++	+++	+++	+	-

Oligo per., persistent oligoarticular; oligo ext., extended oligoarticular; Poly RF-, polyarticular rheumatoid factor-negative; NP, not present; T-B, aggregates of T and B cells; GC, T and B cell aggregates with germinal centre (GC)-like reaction. Scoring: -, absence of positive cells in high-power field; +, 1–10 positive cells per high-power field; ++, 10–20 positive cells per high-power field; +++, more than 20 positive cells per high-power field (see also the Methods section). Lining, lining layer and superficial subintima; sublining, perivascular infiltrates in sublining layer; aggregates, T and B cell aggregates with or without GC-like reaction. All evaluations were performed in areas characterised by a clear lymphocyte (anti-CD3 and anti-CD4 positive cells) infiltration (see also the Methods section and Fig. 3).

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