Table 1 Demographic, biopsy, and clinical data for 120 patients given salivary gland biopsies for Sjögren's syndrome (SS)
Clinical and laboratory parameters | FSa = 0 | 0 < FS < 1 | 1 ≤ FS < 2 | FS ≥ 2 |
|---|---|---|---|---|
No. of patients | 57 | 11 | 15 | 37 |
Sex | 9M/48F | 1 M/10 F | 0 M/15 F | 3 M/34 F |
Age (years) | 46 ± 12 | 46 ± 11 | 54 ± 14 | 56 ± 13 |
Baseline biopsy area (mm2) | 6.1 ± 5.6 | 8.3 ± 2.8 | 8.6 ± 4.3 | 4.7 ± 2.6 |
Cumulative area of three biopsies (mm2) | 17.1 ± 15.1 | 21.8 ± 9.3 | 22.6 ± 12.7 | 12.9 ± 6.4 |
Findings [No. (%)] | ||||
Dry eyes | 49 (86) | 9 (81) | 14 (93) | 33 (89) |
Xerostomia | 45 (79) | 7 (63) | 14 (93) | 35 (94) |
Positive Schirmer's test | 24 (42) | 4 (36) | 9 (60) | 18 (51) |
Reduced salivary flow rate | 30 (53) | 7 (63) | 13 (86) | 34 (91) |
Antinuclear antibodies | 29 (51) | 8 (73) | 8 (53) | 31 (83) |
Ro/SS-A | 18 (31) | 3 (27) | 6 (40) | 25 (67) |
La/SS-B | 3 (5) | 0 | 3 (20) | 10 (27) |
Rheumatoid factor | 27 (47) | 5 (45) | 7 (46) | 33 (89) |
SS according to AECG criteria [No. (%)] | 7 (12) | 1 (9) | 15 (100) | 34 (92) |
SS according to clinical re-evaluation [No. (%)] | 7 (12) | 0 (0) | 8 (53) | 34 (92) |