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Table 1 Demographic, biopsy, and clinical data for 120 patients given salivary gland biopsies for Sjögren's syndrome (SS)

From: Multilevel examination of minor salivary gland biopsy for Sjögren's syndrome significantly improves diagnostic performance of AECG classification criteria

Clinical and laboratory parameters FSa = 0 0 < FS < 1 1 ≤ FS < 2 FS ≥ 2
No. of patients 57 11 15 37
Sex 9M/48F 1 M/10 F 0 M/15 F 3 M/34 F
Age (years) 46 ± 12 46 ± 11 54 ± 14 56 ± 13
Baseline biopsy area (mm2) 6.1 ± 5.6 8.3 ± 2.8 8.6 ± 4.3 4.7 ± 2.6
Cumulative area of three biopsies (mm2) 17.1 ± 15.1 21.8 ± 9.3 22.6 ± 12.7 12.9 ± 6.4
Findings [No. (%)]     
   Dry eyes 49 (86) 9 (81) 14 (93) 33 (89)
   Xerostomia 45 (79) 7 (63) 14 (93) 35 (94)
   Positive Schirmer's test 24 (42) 4 (36) 9 (60) 18 (51)
   Reduced salivary flow rate 30 (53) 7 (63) 13 (86) 34 (91)
   Antinuclear antibodies 29 (51) 8 (73) 8 (53) 31 (83)
   Ro/SS-A 18 (31) 3 (27) 6 (40) 25 (67)
   La/SS-B 3 (5) 0 3 (20) 10 (27)
   Rheumatoid factor 27 (47) 5 (45) 7 (46) 33 (89)
SS according to AECG criteria [No. (%)] 7 (12) 1 (9) 15 (100) 34 (92)
SS according to clinical re-evaluation [No. (%)] 7 (12) 0 (0) 8 (53) 34 (92)
  1. aThe focus score (FS) is the number of inflammatory infiltrates of at least 50 cells present in 4 mm2 of salivary gland area. AECG, American-European Consensus Group; F, female; M, male; SS-A, anti-Ro60 antibodies; SS-B, anti-La antibodies.