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Table 2 Changes in classification determined by multilevel salivary gland biopsies for Sjögren's syndrome (SS)

From: Multilevel examination of minor salivary gland biopsy for Sjögren's syndrome significantly improves diagnostic performance of AECG classification criteria

Test results and diagnostic accuracy

FSa = 0

0 < FS < 1

1 ≤ FS < 2

FS ≥ 2

Total

No. of patients

57

11

15

37

120

AECG classification changes

0

0

6 (40°%)

1 (3%)

7

Baseline sensitivity (95% CI)

85.7%

(42.2–97.6)

-

100%

(62.9–100)

94.1%

(80.3–99.1)

93.9%

(83.1–98.6)

Revised sensitivity (95% CI)

85.7%

(42.2–97.6)

-

100%

(62.9–100)

94.1%

(80.3–99.1)

93.9%

(83.1–98.6)

Baseline specificity (95% CI)

98%

(89.3–99.7)

-

0%b

(0–41.1)

33.3%b

(5.5–88.4)

84.5%

(74.0–92.0)

Revised specificity (95% CI)

98%

(89.3–99.7)

-

85.7%

(42.2–97.6)

66.7%

(11.6–94.5)

94.4%

(86.2–98.4)

  1. aThe focus score (FS) is the number of inflammatory infiltrates of at least 50 cells present in 4 mm2 of salivary gland area. bVery low specificity is due to the absence (1 ≤ FS < 2) or extremely low number (FS ≥ 2) of patients classified as non-SS according to AECG criteria. AECG: American-European Consensus Group; CI: confidence interval; -, could not be evaluated with the available data.