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Table 2 Changes in classification determined by multilevel salivary gland biopsies for Sjögren's syndrome (SS)

From: Multilevel examination of minor salivary gland biopsy for Sjögren's syndrome significantly improves diagnostic performance of AECG classification criteria

Test results and diagnostic accuracy FSa = 0 0 < FS < 1 1 ≤ FS < 2 FS ≥ 2 Total
No. of patients 57 11 15 37 120
AECG classification changes 0 0 6 (40°%) 1 (3%) 7
Baseline sensitivity (95% CI) 85.7%
(42.2–97.6)
- 100%
(62.9–100)
94.1%
(80.3–99.1)
93.9%
(83.1–98.6)
Revised sensitivity (95% CI) 85.7%
(42.2–97.6)
- 100%
(62.9–100)
94.1%
(80.3–99.1)
93.9%
(83.1–98.6)
Baseline specificity (95% CI) 98%
(89.3–99.7)
- 0%b
(0–41.1)
33.3%b
(5.5–88.4)
84.5%
(74.0–92.0)
Revised specificity (95% CI) 98%
(89.3–99.7)
- 85.7%
(42.2–97.6)
66.7%
(11.6–94.5)
94.4%
(86.2–98.4)
  1. aThe focus score (FS) is the number of inflammatory infiltrates of at least 50 cells present in 4 mm2 of salivary gland area. bVery low specificity is due to the absence (1 ≤ FS < 2) or extremely low number (FS ≥ 2) of patients classified as non-SS according to AECG criteria. AECG: American-European Consensus Group; CI: confidence interval; -, could not be evaluated with the available data.