Table 2 Characteristics of the study population
Traditional nonselective NSAIDs (n = 12,418) | Celecoxib (n = 42,422) | Rofecoxib (n = 25,674) | |
|---|---|---|---|
Age (years) | |||
18–34 | 18.6 | 3.7 | 6.7 |
35–44 | 15.8 | 6.5 | 9.7 |
45–54 | 13.2 | 9.9 | 12.1 |
55–64 | 13.5 | 15.9 | 16.4 |
65–74 | 18.8 | 30.5 | 27.1 |
75–84 | 15.1 | 27.1 | 22.7 |
85+ | 4.1 | 6.5 | 5.1 |
Sex | |||
Female | 55.4 | 67.4 | 65.5 |
Male | 44.6 | 32.6 | 34.5 |
Income level | |||
Low | 14.8 | 10.9 | 11.4 |
Nonlow | 85.2 | 89.1 | 88.6 |
Dosage category | |||
High | 11.6 | 31.2 | 8.8 |
Standard | 66.3 | 65.3 | 73.0 |
Low | 22.1 | 3.4 | 18.2 |
Prior diagnosis of gastropathy | 3.6 | 7.7 | 5.0 |
Prior gastrointestinal procedures | 2.0 | 4.5 | 2.7 |
Prior dispensation of gastroprotective agents | 14.0 | 29.9 | 24.3 |
Prior referral to a gastroenterologist | 2.8 | 6.0 | 3.9 |
History of NSAID use | |||
Recent, first time | 3.0 | 2.2 | 2.8 |
Recent, chronic | 6.6 | 4.3 | 4.2 |
>1 to 3 months | 15.7 | 7.8 | 6.3 |
>3 to 12 months | 19.4 | 22.0 | 14.0 |
No use | 55.2 | 63.7 | 72.8 |
Anticoagulants | 1.3 | 3.3 | 3.0 |
Corticosteroids | 11.7 | 19.6 | 16.9 |
Benzodiazepines | 23.3 | 38.2 | 33.0 |
Antidepressants | 10.5 | 17.2 | 15.7 |
Chronic Disease Score | |||
≥10 | 5.2 | 10.3 | 8.2 |
5–9 | 19.6 | 28.6 | 25.4 |
1–4 | 27.9 | 33.6 | 32.6 |
0 | 47.3 | 27.6 | 33.8 |
Prescriber specialty | |||
General practitioner | 85.9 | 85.3 | 88.3 |
Cardiology | 1.0 | 0.4 | 0.3 |
Internal Medicine | 2.3 | 3.3 | 2.1 |
Neurology | 0.3 | 0.3 | 0.2 |
General surgery | 1.4 | 0.8 | 1.0 |
Obstetrics/gynaecology | 1.5 | 0.2 | 0.3 |
Orthopaedic surgery | 1.2 | 3.4 | 3.2 |
Rheumatology | 2.5 | 2.5 | 1.7 |
Other | 2.8 | 3.8 | 2.9 |