Figure 1From: TLR2 modulates inflammation in zymosan-induced arthritis in miceBiphasic kinetic of inflammation in zymosan-induced arthritis (ZIA). (a) 99mTc uptake measurement shows a biphasic course of inflammation in wild-type (WT) mice. Zymosan was injected into the right knee and PBS was injected into the contralateral control knee. The values obtained correspond to the ratio between the right and left knee (n = 15). The severity of histological signs of arthritis was assessed by scoring synovial thickness and cartilage destruction on a scale from 0 to 6. Results are expressed as means ± SEM. (b) WT mice with ZIA showed mild inflammation at day 8 as judged by cellular infiltration (histological score 1.00 ± 0.32) and cartilage destruction (0.7 ± 0.2; n = 10), which became more severe at day 25. (c) There was an increase in cellular infiltration (2.5 ± 0.37) but cartilage destruction remained slight (0.71 ± 0.21; n = 10). The arrows in (b) and (c) indicate inflammatory infiltrate in the synovial membrane.Back to article page