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Table 1 Histopathological features and scoring systems used to evaluate synovial inflammation

From: Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy

Feature Scoring system
Assessed by histology  
   Lining-layer hyperplasia Semiquantitative
   Degree of vascularity Semiquantitative
   Inflammatory infiltration Semiquantitative
   Lymphoid aggregates Present or absent
   Plasma cells Semiquantitative
   Polymorphonuclear leukocytes Semiquantitative
Assessed by immunohistochemistry  
   CD1a Present or absent
   CD3 Semiquantitative
   CD20 Semiquantitative
   CD68 lining layer Semiquantitative
   CD68 sublining layer Semiquantitative
   CD163 lining layer Semiquantitative
   CD163 sublining layer Semiquantitative
   Intracellular citrullinated peptides Present or absent
   MHC class II–HC gp39 peptide complex, recognized by mAb 12A Present or absent