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Table 1 Histopathological features and scoring systems used to evaluate synovial inflammation

From: Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy

Feature

Scoring system

Assessed by histology

 

   Lining-layer hyperplasia

Semiquantitative

   Degree of vascularity

Semiquantitative

   Inflammatory infiltration

Semiquantitative

   Lymphoid aggregates

Present or absent

   Plasma cells

Semiquantitative

   Polymorphonuclear leukocytes

Semiquantitative

Assessed by immunohistochemistry

 

   CD1a

Present or absent

   CD3

Semiquantitative

   CD20

Semiquantitative

   CD68 lining layer

Semiquantitative

   CD68 sublining layer

Semiquantitative

   CD163 lining layer

Semiquantitative

   CD163 sublining layer

Semiquantitative

   Intracellular citrullinated peptides

Present or absent

   MHC class II–HC gp39 peptide complex, recognized by mAb 12A

Present or absent