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Table 2 Synovial histopathology in spondyloarthropathy and rheumatoid arthritis

From: Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy

Feature Spondyloarthropathya Rheumatoid arthritisa
Lining-layer thickness 1 (1–3)* 1.5 (1–3)*
Vascularity 2 (0–3)* 1.5 (0–3)*
Inflammatory infiltration 1.5 (0–3) 2 (0–3)
Plasma cells 0 (0–3) 0 (0–3)
Polymorphonuclear leukocytes 0 (0–3) 0 (0–2.5)
CD3 1.5 (0–3) 2 (0–3)
CD20 1 (0–3) 1.5 (0–3)
CD68 in lining layer 1 (0–3) 1 (0–3)
CD68 in sublining layer 0.5 (0–3) 1 (0–3)
CD163 in lining layer 1.5 (0–3)* 0.5 (0–3)*
CD163 in sublining layer 1.5 (0–3)* 0.5 (0–3)*
Lymphoid aggregates 17/65* 32/54*
CD1a 18/64* 36/50*
Anticitrulline staining 0/82* 27/59*
mAb 12A staining 1/81* 28/58*
  1. aResults are expressed as median (range) for semiquantitative scores and present/absent for dichotomous parameters. As indictated in Materials and methods, stained sections were scored by two blinded observers using a semiquantitative scale from 0 (lowest expression) to 3 (highest level of expression). This scale was calibrated for each marker separately and the mean of the two scores was used.
  2. *P < 0.05.