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Table 3 Association of single histopathological features with three measures of disease activity in spondyloarthropathy (top) and in rheumatoid arthritis (bottom)

From: Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy

Histological feature SJC CRP ESR
  Correlationa SAM Correlationa SAM Correlationa SAM
In spondylarthropathy
Lining-layer thickness 0.220 2.16 0.242 NS 0.240 2.30
Vascularity NS NS NS NS NS NS
Inflammatory infiltration NS NS 0.472 2.60 0.336 2.34
Plasma cells NS NS NS NS NS NS
PMNs NS NS 0.393 2.15 0.280 2.58
CD3 NS NS 0.236 NS NS NS
CD20 NS NS NS NS NS NS
Lining CD68 NS NS -0.510 NS -0.372 NS
Sublining CD68 0.278 3.14 NS NS NS NS
Lining CD163 NS NS NS NS NS NS
Sublining CD163 0.281 2.14 0.249 2.06 0.299 3.18
Lymphoid aggregates NS 2.23 NS NS NS NS
CD1a NS NS NS NS NS NS
Anticitrulline staining NS NS NS NS NS NS
mAb 12A staining NS NS NS NS NS NS
In rheumatoid arthritis
Lining-layer thickness 0.222 NS NS NS NS NS
Vascularity NS NS NS NS -0.235 NS
Inflammatory infiltration NS NS NS NS NS NS
Plasma cells NS NS NS NS 0.212 NS
PMNs -0.255 NS NS NS NS NS
CD3 NS NS 0.297 2.02 0.334 2.49
CD20 NS NS NS NS NS NS
Lining CD68 NS NS -0.227 NS NS NS
Sublining CD68 NS NS NS NS 0.304 2.31
Lining CD163 NS NS NS NS NS NS
Sublining CD163 NS NS NS NS NS NS
Lymphoid aggregates NS NS NS NS NS NS
CD1a NS NS NS NS NS NS
Anticitrulline staining NS NS NS NS P = 0.004 2.84
mAb 12A NS NS P = 0.035 2.00 NS NS
  1. Only significant associations are shown. aCorrelations were calculated either by classicial statistics (results are expressed as correlation coefficient; for dichotomous parameters differences between the positive and negative group are expressed as P on Student's unpaired t-test) or by SAM (significance analysis of microarray) (for which results are expressed as d values). CRP, serum C-reactive protein; ESR, erythrocyte sedimentation rate; NS, not significant; PMNs, polymorphonuclear leukocytes; SJC, swollen joint count.