Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy

Table 3 Association of single histopathological features with three measures of disease activity in spondyloarthropathy (top) and in rheumatoid arthritis (bottom)

Histological feature	SJC		CRP		ESR
	Correlation^a	SAM	Correlation^a	SAM	Correlation^a	SAM
*In spondylarthropathy*
Lining-layer thickness	0.220	2.16	0.242	NS	0.240	2.30
Vascularity	NS	NS	NS	NS	NS	NS
Inflammatory infiltration	NS	NS	0.472	2.60	0.336	2.34
Plasma cells	NS	NS	NS	NS	NS	NS
PMNs	NS	NS	0.393	2.15	0.280	2.58
CD3	NS	NS	0.236	NS	NS	NS
CD20	NS	NS	NS	NS	NS	NS
Lining CD68	NS	NS	-0.510	NS	-0.372	NS
Sublining CD68	0.278	3.14	NS	NS	NS	NS
Lining CD163	NS	NS	NS	NS	NS	NS
Sublining CD163	0.281	2.14	0.249	2.06	0.299	3.18
Lymphoid aggregates	NS	2.23	NS	NS	NS	NS
CD1a	NS	NS	NS	NS	NS	NS
Anticitrulline staining	NS	NS	NS	NS	NS	NS
mAb 12A staining	NS	NS	NS	NS	NS	NS
*In rheumatoid arthritis*
Lining-layer thickness	0.222	NS	NS	NS	NS	NS
Vascularity	NS	NS	NS	NS	-0.235	NS
Inflammatory infiltration	NS	NS	NS	NS	NS	NS
Plasma cells	NS	NS	NS	NS	0.212	NS
PMNs	-0.255	NS	NS	NS	NS	NS
CD3	NS	NS	0.297	2.02	0.334	2.49
CD20	NS	NS	NS	NS	NS	NS
Lining CD68	NS	NS	-0.227	NS	NS	NS
Sublining CD68	NS	NS	NS	NS	0.304	2.31
Lining CD163	NS	NS	NS	NS	NS	NS
Sublining CD163	NS	NS	NS	NS	NS	NS
Lymphoid aggregates	NS	NS	NS	NS	NS	NS
CD1a	NS	NS	NS	NS	NS	NS
Anticitrulline staining	NS	NS	NS	NS	P = 0.004	2.84
mAb 12A	NS	NS	P = 0.035	2.00	NS	NS

Only significant associations are shown. ^aCorrelations were calculated either by classicial statistics (results are expressed as correlation coefficient; for dichotomous parameters differences between the positive and negative group are expressed as P on Student's unpaired t-test) or by SAM (significance analysis of microarray) (for which results are expressed as d values). CRP, serum C-reactive protein; ESR, erythrocyte sedimentation rate; NS, not significant; PMNs, polymorphonuclear leukocytes; SJC, swollen joint count.

ISSN: 1478-6362