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Figure 1 | Arthritis Res Ther

Figure 1

From: Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases

Figure 1

Regulatory T cells mediate inflammatory and immune reactions. CD4+CD25+ Treg can suppress CD4+CD25- T cell responses to antigens through a contact-dependent, antigen-nonspecific mechanism involving TGF-β. Treg suppress CD4+CD25- responder T cell proliferation and cytokine production, reining in Th1 and/or Th2 immunity. Without adequate intercession by Treg, Th1- or Th2-dominated responses may become pathogenic.

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