Figure 2
From: Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases
Treg expanded in vitro suppress allergen-induced asthma in vivo. Mice sensitized to house dust mite (HDM) by intraperitoneal (ip) injection with HDM on days 0 and 7 and then challenged by intratracheal (it) injection on days 14 and 21 were injected intraperitoneally on days 0 and 14 with Treg. Three days after the second intratracheal challenge with HDM, the lungs were assessed for histopathology by periodic acid Schiff staining for mucopolysaccharides (red). Inflammatory pathology and mucin obstruction of the airways were strikingly reduced in mice receiving Treg [12].