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Table 3 Changes (fold change relative to day 0) in cytokine protein concentrations during rat AIA

From: Expression of cytokine mRNA and protein in joints and lymphoid organs during the course of rat antigen-induced arthritis

Time point IL-1β IL-6 TNF-α IL-2 IFN-γ IL-4 IL-10
Inguinal lymph node
Day 0 1.00 (0.27) 1.00 (0.26) 1.00 (0.26) 1.00 (0.31) 1.00 (0.28) 1.00 (0.25) 1.00 (0.20)
6 hours 1.67 (0.60) 0.98 (0.38) 1.93 (0.78) 1.06 (0.31) 0.98 (0.25) 1.38 (0.55) 1.60 (0.32)
Day 1 1.74 (0.58) 0.59 (0.42) 2.53 (0.78) 1.31 (0.45) 1.14 (0.34) 1.86 (0.72) 2.18* (0.49)
Day 3 1.24 (0.29) 0.40 (0.21) 1.38 (0.28) 0.66 (0.12) 0.55 (0.11) 0.53 (0.28) 1.41 (0.24)
Day 6 1.86* (0.41 0.10* (0.10) 1.87 (0.38) 0.69 (0.14) 0.81 (0.12) 0.91 (0.27) 0.89 (0.17)
Spleen
Day 0 1.00 (0.12) 1.00 (0.41) 1.00 (0.10) 1.00 (0.23) 1.00 (0.13) 1.00 (0.12) 1.00 (0.05)
6 hours 0.75 (0.09) 0.32 (0.14) 0.61* (0.04) 0.70 (0.07) 0.78 (0.04) 0.77 (0.04) 0.94 (0.06)
Day 1 0.72 (0.11) 0.41 (0.17) 0.95 (0.13) 0.84 (0.16) 0.81 (0.07) 0.80 (0.08) 0.87 (0.08)
Day 3 0.81 (0.06) 0.24 (0.14) 1.07 (0.08) 0.70 (0.13) 0.71 (0.06) 0.85 (0.06) 0.90 (0.06)
Day 6 0.67 (0.06) 0.82*+ (0.07) 1.36 (0.21) 1.10*+ (0.13) 0.91+ (0.06) 0.96 (0.10) 0.99 (0.07)
  1. Values (fold changes) are means (standard error of the mean) (n = 5 to 6 rats for each time point). AIA, antigen-induced arthritis. *P ≤ 0.05 in comparison with day 0; +P ≤ 0.05 in comparison with the preceding date.