Amplification of autoimmune disease by infection

Table 2 Characteristics of human herpesviruses, Chlamydiae and parvovirus

Organism	Receptors	Main cellular tropism	Proposed latency cell	Other tropism	References
EBV	CD21, MHC-II, α5β1 integrin	B	B	EPC, EC	[8]
CMV	EGFR	M/M	M/M; EC	N, EPC, EC	[174]
HHV6	CD46+	M/M, T, B	M/M	N, EPC	[175]
HHV7	CD4⁺ heparan sulfate receptor	T	M/M	N, EPC, EC	[176,177]
HHV8	Heparan sulfate receptor, EGFR	EC, M/M, B, T	B	N, EPC	[174,178]
Chlamydia pneumoniae	Heparan sulfate receptor	M/M		EC, EPC	[179]
Chlamydia trachomatis		M/M		EC, EPC
Parvovirus B19	Erythrocyte P antigen	Erythroid precursors		EC	[66,67]

B, B cells; CMV, cytomegalovirus; EBV, Epstein–Barr virus; EC, endothelial cells; EGFR, epidermal growth factor receptor; EPC, epithelial cells; HHV, human herpesvirus; MHC, major histocompatibility complex; M/M, myelomonocytic cells; N, neural cells; T, T cells.

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