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Table 1 Histological scoring of synovitis and cartilage damage in the tarsal joints from HLA-B27 transgenic rats

From: The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthritis

Group Synovial structure (0–3) Fibroplasia (0–3) Inflammatory cells (0–3) Pannus (0–2) Total synovitis score (0–11)
T/MC vehicle 3.00 ± 0.00 2.80 ± 0.45 3.00 ± 0.00 1.60 ± 0.89 10.40 ± 1.34
WAY-169916, 10 mg/kg 1.80 ± 0.45* 1.20 ± 0.84* 1.40 ± 0.55* 0.40 ± 0.89 5.00 ± 2.24*
Prednisolone, 0.6 mg/kg 2.40 ± 0.55 2.00 ± 0.71* 2.00 ± 0.00* 1.60 ± 0.89 8.00 ± 1.87
Group Cartilage structure (0–6) Cartilage cells Safranin-O/Fast Green staining (0–4) Tidemark integrity (0–2) Total Mankin score
T/MC vehicle 3.80 ± 0.84 2.80 ± 0.45 3.20 ± 0.45 0 9.80 ± 1.48
WAY-169916, 10 mg/kg 2.20 ± 0.45* 2.00 ± 0.45* 1.60 ± 0.55* 0 5.80 ± 0.84*
Prednisolone, 0.6 mg/kg 3.40 ± 0.55 2.20 ± 0.45* 3.00 ± 0.00 0 8.60 ± 0.89
  1. Results are means ± SD.
  2. *Significantly less than vehicle (P < 0.005). Significantly less than prednisolone (P < 0.005).