The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthritis

Table 1 Histological scoring of synovitis and cartilage damage in the tarsal joints from HLA-B27 transgenic rats

Group	Synovial structure (0–3)	Fibroplasia (0–3)	Inflammatory cells (0–3)	Pannus (0–2)	Total synovitis score (0–11)
T/MC vehicle	3.00 ± 0.00	2.80 ± 0.45	3.00 ± 0.00	1.60 ± 0.89	10.40 ± 1.34
WAY-169916, 10 mg/kg	1.80 ± 0.45*	1.20 ± 0.84*	1.40 ± 0.55*^†	0.40 ± 0.89	5.00 ± 2.24*^†
Prednisolone, 0.6 mg/kg	2.40 ± 0.55	2.00 ± 0.71*	2.00 ± 0.00*	1.60 ± 0.89	8.00 ± 1.87
Group	Cartilage structure (0–6)	Cartilage cells	Safranin-O/Fast Green staining (0–4)	Tidemark integrity (0–2)	Total Mankin score
T/MC vehicle	3.80 ± 0.84	2.80 ± 0.45	3.20 ± 0.45	0	9.80 ± 1.48
WAY-169916, 10 mg/kg	2.20 ± 0.45*^†	2.00 ± 0.45*^†	1.60 ± 0.55*^†	0	5.80 ± 0.84*^†
Prednisolone, 0.6 mg/kg	3.40 ± 0.55	2.20 ± 0.45*	3.00 ± 0.00	0	8.60 ± 0.89

Results are means ± SD.
*Significantly less than vehicle (P < 0.005). ^†Significantly less than prednisolone (P < 0.005).

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