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Table 2 Histological scoring of synovitis and cartilage changes in the tarsal joints from rats with adjuvant-induced arthritis

From: The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthritis

Group Synovial structure (0–3) Fibroplasia (0–3) Inflammatory cells (0–3) Pannus (0–2) Total synovitis score (0–11)
T/MC vehicle 2.92 ± 0.21 2.67 ± 0.41 2.92 ± 0.21 2.00 ± 0.00 10.5 ± 0.63
WAY-169916, 0.3 mg/kg 2.33 ± 0.41* 2.33 ± 0.52 1.58 ± 0.38* 1.17 ± 0.75 7.42 ± 1.88*
WAY-169916, 0.1 mg/kg 2.17 ± 0.68* 1.92 ± 0.49* 1.50 ± 0.45* 0.83 ± 0.98* 6.42 ± 2.90*
Group Cartilage structure (0–6) Cartilage cells (0–3) Safranin-O/Fast Green staining (0–4) Tidemark integrity (0–1) Total Mankin score (0–14)
T/MC vehicle 3.52 ± 0.42 2.33 ± 0.41 3.00 ± 0.00 0 8.58 ± 0.74
WAY-169916, 0.3 mg/kg 1.75 ± 0.69* 1.58 ± 0.38* 1.83 ± 0.41* 0 5.17 ± 1.77*
WAY-169916, 0.1 mg/kg 2.25 ± 0.42* 1.42 ± 0.49* 1.67 ± 0.41* 0 5.33 ± 1.21*
  1. Results are means ± SD.
  2. *Significantly less than vehicle (P < 0.005).