Group | Synovial structure (0–3) | Fibroplasia (0–3) | Inflammatory cells (0–3) | Pannus (0–2) | Total synovitis score (0–11) |
---|---|---|---|---|---|
T/MC vehicle | 2.92 ± 0.21 | 2.67 ± 0.41 | 2.92 ± 0.21 | 2.00 ± 0.00 | 10.5 ± 0.63 |
WAY-169916, 0.3 mg/kg | 2.33 ± 0.41* | 2.33 ± 0.52 | 1.58 ± 0.38* | 1.17 ± 0.75 | 7.42 ± 1.88* |
WAY-169916, 0.1 mg/kg | 2.17 ± 0.68* | 1.92 ± 0.49* | 1.50 ± 0.45* | 0.83 ± 0.98* | 6.42 ± 2.90* |
Group | Cartilage structure (0–6) | Cartilage cells (0–3) | Safranin-O/Fast Green staining (0–4) | Tidemark integrity (0–1) | Total Mankin score (0–14) |
T/MC vehicle | 3.52 ± 0.42 | 2.33 ± 0.41 | 3.00 ± 0.00 | 0 | 8.58 ± 0.74 |
WAY-169916, 0.3 mg/kg | 1.75 ± 0.69* | 1.58 ± 0.38* | 1.83 ± 0.41* | 0 | 5.17 ± 1.77* |
WAY-169916, 0.1 mg/kg | 2.25 ± 0.42* | 1.42 ± 0.49* | 1.67 ± 0.41* | 0 | 5.33 ± 1.21* |