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Table 3 WAY-169916 gene-profiling experiment with spleen from rat adjuvant arthritis model

From: The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthritis

  Av. control Av. CFA Av. CFA + WAY-169916 AFC CFA AFC WAY-169916 Inhibition by WAY-169916 (%)
Transcription factors       
   CCAAT/enhancer binding protein (C/EBP), beta 16.8 39.8 19.6 2.37 0.49 87.6
   NF-E2-related factor 2 14.2 30.3 19.6 2.13 0.65 66.2
Immune mediators       
   Mast cell protease 2 5.3 11.8 5.9 2.20 0.50 91.4
   Arachidonate 5-lipoxygenase-activating protein 18.9 46.5 23.9 2.46 0.51 82.0
   Chemokine-like factor 1 10.5 28.9 18.9 2.75 0.65 54.3
   Phospholipase A2, group IIA 33.8 71.7 60.3 2.12 0.84 30.0
   Proteoglycan 2, bone marrow 27.6 147.4 59.1 5.34 0.40 73.7
Immune related       
   CD14 antigen 15.9 32.3 19.1 2.04 0.59 80.2
   Peptidoglycan recognition protein 10.2 39.6 14.5 3.88 0.37 85.2
   Lipopolysaccharide-binding protein 3.3 10.2 4.4 3.10 0.43 83.6
   IL-1 receptor, type II 2.2 8.1 3.5 3.71 0.44 76.8
   Defensin RatNP-3 precursor 31.7 105.3 63.5 3.32 0.60 56.8
   Suppressor of cytokine signalling 3 15.2 35.3 15.2 2.33 0.43 99.7
   Complement component 3 13.3 28.4 24.2 2.14 0.85 27.6
   Defensin NP-2 precursor 58.9 166.6 102.8 2.83 0.62 59.3
   Defensin NP-4 precursor 54.1 164.9 104.7 3.05 0.64 54.3
   Paired immunoglobulin-like receptor-B 11.0 22.7 18.3 2.07 0.81 37.6
   25 oligoadenylate synthetase 24.6 51.4 24.8 2.09 0.48 99.2
   Tumor necrosis factor receptor II 7.3 15.8 8.9 2.18 0.56 81.0
   S100 calcium-binding protein A8 (calgranulin A) 52.2 184.5 91.5 3.54 0.50 70.3
   S100 calcium-binding protein A9 (calgranulin B) 144.9 382.7 242.1 2.64 0.63 59.1
   Ficolin B 42.3 121.1 74.7 2.86 0.62 58.9
   Myelin and lymphocyte protein 11.8 27.6 19.9 2.34 0.72 49.1
Protease       
   Matrix metalloproteinase 9 2.0 8.4 3.5 4.24 0.42 75.8
   Chymase 1 2.9 9.2 5.1 3.16 0.56 64.8
Transport       
   Monocarboxylate transporter 10.3 24.4 10.0 2.38 0.41 102.3
   Lipocalin 2 16.3 55.3 33.0 3.39 0.60 57.1
Acute phase       
   Haptoglobin 10.5 37.5 12.9 3.58 0.34 90.9
Metabolism       
   Uridine phosphorylase I 8.9 32.8 9.1 3.68 0.28 99.3
   Guanine deaminase 17.8 39.5 20.7 2.21 0.52 86.9
   Microsomal glutathione S-transferase 1 40.0 87.6 51.2 2.19 0.58 76.6
   GTP cyclohydrolase 1 11.6 25.5 23.6 2.20 0.93 13.8
   Hepatic steroid hydroxylase II A2 9.0 18.7 21.5 2.07 1.15 -29.0
Adhesion       
   C-CAM4 protein 11.5 24.5 16.0 2.12 0.65 65.6
   Fibronectin 1 57.2 116.6 91.3 2.04 0.78 42.6
Unknown function       
   Expressed sequence tag 20.0 41.5 25.1 2.08 0.61 76.1
  1. AFC, average fold change; Av., average; CFA, complete Freund's adjuvant.