Table 3 WAY-169916 gene-profiling experiment with spleen from rat adjuvant arthritis model
Av. control | Av. CFA | Av. CFA + WAY-169916 | AFC CFA | AFC WAY-169916 | Inhibition by WAY-169916 (%) | |
|---|---|---|---|---|---|---|
Transcription factors | ||||||
CCAAT/enhancer binding protein (C/EBP), beta | 16.8 | 39.8 | 19.6 | 2.37 | 0.49 | 87.6 |
NF-E2-related factor 2 | 14.2 | 30.3 | 19.6 | 2.13 | 0.65 | 66.2 |
Immune mediators | ||||||
Mast cell protease 2 | 5.3 | 11.8 | 5.9 | 2.20 | 0.50 | 91.4 |
Arachidonate 5-lipoxygenase-activating protein | 18.9 | 46.5 | 23.9 | 2.46 | 0.51 | 82.0 |
Chemokine-like factor 1 | 10.5 | 28.9 | 18.9 | 2.75 | 0.65 | 54.3 |
Phospholipase A2, group IIA | 33.8 | 71.7 | 60.3 | 2.12 | 0.84 | 30.0 |
Proteoglycan 2, bone marrow | 27.6 | 147.4 | 59.1 | 5.34 | 0.40 | 73.7 |
Immune related | ||||||
CD14 antigen | 15.9 | 32.3 | 19.1 | 2.04 | 0.59 | 80.2 |
Peptidoglycan recognition protein | 10.2 | 39.6 | 14.5 | 3.88 | 0.37 | 85.2 |
Lipopolysaccharide-binding protein | 3.3 | 10.2 | 4.4 | 3.10 | 0.43 | 83.6 |
IL-1 receptor, type II | 2.2 | 8.1 | 3.5 | 3.71 | 0.44 | 76.8 |
Defensin RatNP-3 precursor | 31.7 | 105.3 | 63.5 | 3.32 | 0.60 | 56.8 |
Suppressor of cytokine signalling 3 | 15.2 | 35.3 | 15.2 | 2.33 | 0.43 | 99.7 |
Complement component 3 | 13.3 | 28.4 | 24.2 | 2.14 | 0.85 | 27.6 |
Defensin NP-2 precursor | 58.9 | 166.6 | 102.8 | 2.83 | 0.62 | 59.3 |
Defensin NP-4 precursor | 54.1 | 164.9 | 104.7 | 3.05 | 0.64 | 54.3 |
Paired immunoglobulin-like receptor-B | 11.0 | 22.7 | 18.3 | 2.07 | 0.81 | 37.6 |
25 oligoadenylate synthetase | 24.6 | 51.4 | 24.8 | 2.09 | 0.48 | 99.2 |
Tumor necrosis factor receptor II | 7.3 | 15.8 | 8.9 | 2.18 | 0.56 | 81.0 |
S100 calcium-binding protein A8 (calgranulin A) | 52.2 | 184.5 | 91.5 | 3.54 | 0.50 | 70.3 |
S100 calcium-binding protein A9 (calgranulin B) | 144.9 | 382.7 | 242.1 | 2.64 | 0.63 | 59.1 |
Ficolin B | 42.3 | 121.1 | 74.7 | 2.86 | 0.62 | 58.9 |
Myelin and lymphocyte protein | 11.8 | 27.6 | 19.9 | 2.34 | 0.72 | 49.1 |
Protease | ||||||
Matrix metalloproteinase 9 | 2.0 | 8.4 | 3.5 | 4.24 | 0.42 | 75.8 |
Chymase 1 | 2.9 | 9.2 | 5.1 | 3.16 | 0.56 | 64.8 |
Transport | ||||||
Monocarboxylate transporter | 10.3 | 24.4 | 10.0 | 2.38 | 0.41 | 102.3 |
Lipocalin 2 | 16.3 | 55.3 | 33.0 | 3.39 | 0.60 | 57.1 |
Acute phase | ||||||
Haptoglobin | 10.5 | 37.5 | 12.9 | 3.58 | 0.34 | 90.9 |
Metabolism | ||||||
Uridine phosphorylase I | 8.9 | 32.8 | 9.1 | 3.68 | 0.28 | 99.3 |
Guanine deaminase | 17.8 | 39.5 | 20.7 | 2.21 | 0.52 | 86.9 |
Microsomal glutathione S-transferase 1 | 40.0 | 87.6 | 51.2 | 2.19 | 0.58 | 76.6 |
GTP cyclohydrolase 1 | 11.6 | 25.5 | 23.6 | 2.20 | 0.93 | 13.8 |
Hepatic steroid hydroxylase II A2 | 9.0 | 18.7 | 21.5 | 2.07 | 1.15 | -29.0 |
Adhesion | ||||||
C-CAM4 protein | 11.5 | 24.5 | 16.0 | 2.12 | 0.65 | 65.6 |
Fibronectin 1 | 57.2 | 116.6 | 91.3 | 2.04 | 0.78 | 42.6 |
Unknown function | ||||||
Expressed sequence tag | 20.0 | 41.5 | 25.1 | 2.08 | 0.61 | 76.1 |