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Table 1 Indications for a pathogenic role for CD4+ T cells in rheumatoid inflammation

From: The role of the T cell in autoimmune inflammation

Association of rheumatoid arthritis with HLA-DR4 and HLA-DR1 subtypes (shared epitope)
Enrichment of activated CD4+ memory T cells in peripheral blood, synovial membrane, and synovial fluid
Important role in disease initiation in several animal models of inflammatory arthritis
Clinical efficacy of appropriate T-cell directed therapies