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Table 2 T cell directed therapies in rheumatoid arthritis

From: The role of the T cell in autoimmune inflammation

Intervention Examples
Reduction in T cell number or function Total lymphoid irradiation
  Thoracic duct drainage
Immunosuppressive drugs Glucocorticoids
  Methotrexate
  Leflunomide
  Cyclosporine
  FK 506 (tacrolimus)
  Rapamycin (sirolimus)
Biologicals TCR vaccination
  mAbs to T cell surface receptors
  mAbs to surface receptors on cells interacting with T cells
  Cytokines, mAbs to cytokines
  Inhibitors of T cell/APC interactions
  1. APC, antigen-presenting cell; mAb, monoclonal antibody; TCR, T-cell receptor.