Table 2 T cell directed therapies in rheumatoid arthritis
| Intervention | Examples |
|---|---|
| Reduction in T cell number or function | Total lymphoid irradiation |
| Thoracic duct drainage | |
| Immunosuppressive drugs | Glucocorticoids |
| Methotrexate | |
| Leflunomide | |
| Cyclosporine | |
| FK 506 (tacrolimus) | |
| Rapamycin (sirolimus) | |
| Biologicals | TCR vaccination |
| mAbs to T cell surface receptors | |
| mAbs to surface receptors on cells interacting with T cells | |
| Cytokines, mAbs to cytokines | |
| Inhibitors of T cell/APC interactions |