Table 2 T cell directed therapies in rheumatoid arthritis
Intervention | Examples |
|---|---|
Reduction in T cell number or function | Total lymphoid irradiation |
| Â | Thoracic duct drainage |
Immunosuppressive drugs | Glucocorticoids |
| Â | Methotrexate |
| Â | Leflunomide |
| Â | Cyclosporine |
| Â | FK 506 (tacrolimus) |
| Â | Rapamycin (sirolimus) |
Biologicals | TCR vaccination |
| Â | mAbs to T cell surface receptors |
| Â | mAbs to surface receptors on cells interacting with T cells |
| Â | Cytokines, mAbs to cytokines |
| Â | Inhibitors of T cell/APC interactions |