Table 3 Discontinuations of treatment in arthritis because of lack of efficacy or adverse events
| Â | Â | Â | Lack-of-efficacy discontinuations | Adverse-event discontinuations | ||||
|---|---|---|---|---|---|---|---|---|
Duration (weeks) | Treatment | Dose (mg/day) | Number of events | Total number | Discontinuations, % (95% CI) | Number of events | Total number | Discontinuations, % (95% CI) |
2–6 | Placebo |  | 339 | 1,925 | 17.6 (15.8–19.4) | 97 | 1,925 | 5.0 (4.0–6.0) |
|  | Celecoxib | <100 | 42 | 253 | 16.6 (12.1–21.1) | 8 | 253 | 3.2 (1.0–5.4) |
| Â | Celecoxib | 100 | No data | No data | ||||
|  | Celecoxib | 200 | 203 | 4,190 | 4.8 (4.2–5.4) | 223 | 4,190 | 5.3 (4.7–5.9) |
|  | Celecoxib | 400 | 12 | 155 | 7.7 (3.6–11.8) | 5 | 155 | 3.2 (0.5–5.9) |
|  | Celecoxib | 800 | 15 | 180 | 8.3 (4.2–12.4) | 14 | 180 | 7.8 (3.9–11.7) |
|  | Paracetamol | 4,000 | 55 | 502 | 11.0 (8.3–13.7) | 27 | 502 | 5.4 (3.4–7.4) |
|  | Rofecoxib | 25 | 19 | 1,191 | 1.6 (0.8–2.4) | 77 | 1,191 | 6.5 (5.1–7.9) |
|  | Naproxen | 1,000 | 5 | 395 | 1.3 (0.1–2.5) | 31 | 395 | 7.8 (5.3–10.3) |
|  | Diclofenac | 100/150 | 13 | 540 | 2.4 (1.0–3.8) | 51 | 540 | 9.4 (6.9–11.9) |
12 | Placebo |  | 521 | 1,135 | 45.9 (43.0–48.8) | 70 | 1,135 | 6.2 (4.8–7.6) |
|  | Celecoxib | 100 | 145 | 692 | 21 (18.1–23.9) | 52 | 692 | 7.5 (5.5–9.5) |
|  | Celecoxib | 200 | 571 | 6,094 | 9.4 (8.6–10.2) | 488 | 6,094 | 8.0 (7.4–8.6) |
|  | Celecoxib | 400 | 492 | 6,166 | 8.0 (7.4–8.6) | 590 | 6,166 | 9.6 (8.8–10.4) |
|  | Celecoxib | 800 | 128 | 435 | 29.4 (25.1–33.7) | 28 | 435 | 6.4 (4.0–8.8) |
| Â | Paracetamol | 4,000 | No data | No data | ||||
|  | Rofecoxib | 25 | 1 | 132 | 0.8 (0.0–2.4) | 13 | 132 | 9.8 (4.7–14.9) |
|  | Naproxen | 1,000 | 374 | 2,399 | 15.6 (14.2–17.0) | 316 | 2,399 | 13.2 (11.8–14.6) |
|  | Diclofenac | 100/150 | 120 | 4,311 | 2.8 (2.2–3.4) | 338 | 4,311 | 7.8 (7.0–8.6) |
|  | Ibuprofen | 2,400 | 14 | 345 | 4.1 (1.9–6.3) | 37 | 345 | 10.7 (7.4–14) |
24+ | Placebo | Â | No data | No data | ||||
| Â | Celecoxib | 100 | No data | No data | ||||
| Â | Celecoxib | 200 | No data | No data | ||||
|  | Celecoxib | 400 | 26 | 326 | 8.0 (5.1–10.9) | 34 | 326 | 10.4 (7.1–13.7) |
|  | Celecoxib | 800 | 691 | 3,987 | 17.3 (16.1–18.5) | 892 | 3,987 | 22.4 (21–23.8) |
| Â | Paracetamol | 4,000 | No data | No data | ||||
| Â | Rofecoxib | 25 | No data | No data | ||||
| Â | Naproxen | 1,000 | No data | No data | ||||
|  | Diclofenac | 100/150 | 331 | 2,325 | 14.2 (12.8–15.6) | 593 | 2,325 | 25.5 (23.7–27.3) |
|  | Ibuprofen | 2,400 | 456 | 1,985 | 23.0 (21.2–24.8) | 456 | 1,985 | 23.0 (21.2–24.8) |