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Table 3 Discontinuations of treatment in arthritis because of lack of efficacy or adverse events

From: Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports

    Lack-of-efficacy discontinuations Adverse-event discontinuations
Duration (weeks) Treatment Dose (mg/day) Number of events Total number Discontinuations, % (95% CI) Number of events Total number Discontinuations, % (95% CI)
2–6 Placebo   339 1,925 17.6 (15.8–19.4) 97 1,925 5.0 (4.0–6.0)
  Celecoxib <100 42 253 16.6 (12.1–21.1) 8 253 3.2 (1.0–5.4)
  Celecoxib 100 No data No data
  Celecoxib 200 203 4,190 4.8 (4.2–5.4) 223 4,190 5.3 (4.7–5.9)
  Celecoxib 400 12 155 7.7 (3.6–11.8) 5 155 3.2 (0.5–5.9)
  Celecoxib 800 15 180 8.3 (4.2–12.4) 14 180 7.8 (3.9–11.7)
  Paracetamol 4,000 55 502 11.0 (8.3–13.7) 27 502 5.4 (3.4–7.4)
  Rofecoxib 25 19 1,191 1.6 (0.8–2.4) 77 1,191 6.5 (5.1–7.9)
  Naproxen 1,000 5 395 1.3 (0.1–2.5) 31 395 7.8 (5.3–10.3)
  Diclofenac 100/150 13 540 2.4 (1.0–3.8) 51 540 9.4 (6.9–11.9)
12 Placebo   521 1,135 45.9 (43.0–48.8) 70 1,135 6.2 (4.8–7.6)
  Celecoxib 100 145 692 21 (18.1–23.9) 52 692 7.5 (5.5–9.5)
  Celecoxib 200 571 6,094 9.4 (8.6–10.2) 488 6,094 8.0 (7.4–8.6)
  Celecoxib 400 492 6,166 8.0 (7.4–8.6) 590 6,166 9.6 (8.8–10.4)
  Celecoxib 800 128 435 29.4 (25.1–33.7) 28 435 6.4 (4.0–8.8)
  Paracetamol 4,000 No data No data
  Rofecoxib 25 1 132 0.8 (0.0–2.4) 13 132 9.8 (4.7–14.9)
  Naproxen 1,000 374 2,399 15.6 (14.2–17.0) 316 2,399 13.2 (11.8–14.6)
  Diclofenac 100/150 120 4,311 2.8 (2.2–3.4) 338 4,311 7.8 (7.0–8.6)
  Ibuprofen 2,400 14 345 4.1 (1.9–6.3) 37 345 10.7 (7.4–14)
24+ Placebo   No data No data
  Celecoxib 100 No data No data
  Celecoxib 200 No data No data
  Celecoxib 400 26 326 8.0 (5.1–10.9) 34 326 10.4 (7.1–13.7)
  Celecoxib 800 691 3,987 17.3 (16.1–18.5) 892 3,987 22.4 (21–23.8)
  Paracetamol 4,000 No data No data
  Rofecoxib 25 No data No data
  Naproxen 1,000 No data No data
  Diclofenac 100/150 331 2,325 14.2 (12.8–15.6) 593 2,325 25.5 (23.7–27.3)
  Ibuprofen 2,400 456 1,985 23.0 (21.2–24.8) 456 1,985 23.0 (21.2–24.8)
  1. CI, confidence interval.