|  |  | Number of | Incidence of events (%) |  |  | ||
---|---|---|---|---|---|---|---|---|
Outcome and comparisons | Celecoxib daily dose | Comparator and daily dose | Trials | Patients | Celecoxib | Comparator | Relative riska (95% CI) | NNTpb or NNHc (95% CI) |
Gastrointestinal tolerability | Â | Â | Â | Â | Â | Â | ||
Celecoxib v placebo | Any | Placebo | 19 | 9,919 | 5.3 | 4.6 | 1.0 (0.82–1.2) |  |
Celecoxib v paracetamol | Any | Paracetamol 4,000 mg | 2 | 1,056 | 2.0 | 2.0 | 1.0 (0.43–2.4) |  |
Celecoxib v rofecoxib | Any | Rofecoxib 25 mg | 5 | 2,671 | 3.2 | 4.4 | 0.72 (0.49–1.06) |  |
Celecoxib (200/400) v NSAID | 200–400 mg | NSAID to maximum daily | 19 | 22,615 | 5.4 | 8.9 | 0.62 (0.56–0.68) | 28 (24–36) b |
Celecoxib (any dose) v NSAID | Any | NSAID to maximum daily | 19 | 23,743 | 5.5 | 8.9 | 0.61 (0.55–0.67) | 29 (24–36) b |
Celecoxib (any dose) v any active | Any | Any active comparator | 25 | 27,334 | 5.2 | 8.0 | 0.63 (0.57–0.69) | 35 (29–45) b |
Nausea | Â | Â | Â | Â | Â | Â | ||
Celecoxib v placebo | Any | Placebo | 17 | 9,510 | 2.7 | 3.4 | 0.76 (0.60–0.97) | 155 (71–840) b |
Celecoxib v paracetamol | Any | Paracetamol 4,000 mg | 2 | 1,056 | 2.9 | 1.8 | 1.6 (0.73–3.7) |  |
Celecoxib v rofecoxib | Any | Rofecoxib 25 mg | 4 | 1,579 | 1.8 | 2.8 | 0.62 (0.32–1.2) |  |
Celecoxib (200/400) v NSAID | 200–400 mg | NSAID to maximum daily | 17 | 22,072 | 2.7 | 3.3 | 0.87 (0.74–1.02) |  |
Celecoxib (any dose) v NSAID | Any | NSAID to maximum daily | 18 | 31,168 | 3.8 | 5.6 | 0.80 (0.72–0.89) | 56 (44–77) b |
Celecoxib (any dose) v any active | Any | Any active comparator | 23 | 33,667 | 3.7 | 5.3 | 0.81 (0.73–0.90) | 63 (49–88) b |
Vomiting | Â | Â | Â | Â | Â | Â | ||
Celecoxib v placebo | Any | Placebo | 15 | 9,030 | 1.1 | 0.7 | 1.4 (0.86–2.4) |  |
Celecoxib v paracetamol | Any | Paracetamol 4,000 mg | 2 | 1,056 | 0.7 | 1.0 | 0.73 (0.19–2.7) |  |
Celecoxib v rofecoxib | Any | Rofecoxib 25 mg | 3 | 769 | 1.0 | 0.8 | 1.3 (0.29-5.7) | Â |
Celecoxib (200/400) v NSAID | 200–400 mg | NSAID to maximum daily | 16 | 21,825 | 0.8 | 1.4 | 0.64 (0.49–0.83) | 173 (115–350) b |
Celecoxib (any dose) v NSAID | Any | NSAID to maximum daily | 17 | 30,921 | 1.2 | 1.9 | 0.75 (0.62–0.90) | 144 (100–250) b |
Celecoxib (any dose) v any active | Any | Any active comparator | 21 | 32,610 | 1.2 | 1.9 | 0.76 (0.64–0.91) | 156 (110–280) b |