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Table 4 Concentrations of inflammatory mediators in synovial fluid and plasma from arthritic patients (n = 11)

From: Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes

Mediator Concentration P
  Synovial fluid Plasma  
MCP-1 (pg/ml) 134 (36–522) 34 (15–62) 0.008
sICAM-1 (ng/ml) 706 (226–1,085) 871 (657–1,691) 0.006
IL-8 (pg/ml) 614 (<50–24,630) <50 0.002
IL-6 (pg/ml) 13,897 (35–43,131) 11 (0–57) 0.002
VEGF (pg/ml) 1,604 (528–2,506) 23 (<5–69) 0.002
RANTES (pg/ml) 7 (<5–35) 3,986 (2,920–10,037) 0.001
GM-CSF (pg/ml) <2 (<2–39) <2 (<2–28) 0.125
  1. Results are medians, with ranges in parentheses. Concentrations of all mediators were determined by ELISA as described in the Materials and methods section. GM-CSF, granulocyte/macrophage colony-stimulating factor; MCP-1, monocyte chemoattractant protein-1; sICAM-1, soluble intracellular adhesion molecule-1; VEGF, vascular endothelial growth factor.