Table 3 Spearman correlations among biomarkers and potential cardiovascular risk factors
Cardiovascular risk factor | VCAM-1 (pg/ml) | ICAM-1 (pg/ml) | ELAM-1 (pg/ml) |
|---|---|---|---|
Demographic | Â | Â | Â |
Age (years) | 0.279 | 0.149 | 0.148 |
Lifestyle | Â | Â | Â |
Smoking (cigarettes/day) | 0.209 | 0.253 | 0.062 |
Alcohol (units/week) | 0.209 | 0.112 | -0.072 |
Exercise (hours/week) | 0.034 | 0.085 | -0.055 |
Systemic inflammation | Â | Â | Â |
hs-CRP (mg/l) | 0.289 | 0.189 | 0.217 |
ESR (mm/hour) | 0.217 | 0.175 | 0.195 |
Disease duration (years) | 0.138 | 0.069 | 0.079 |
Disease severity | Â | Â | Â |
Radiographic score | 0.157 | -0.012 | 0.092 |
Rheumatoid factor (IU/ml) | 0.319** | 0.363** | 0.290 |
Cytokines | Â | Â | Â |
TNF-α (pg/ml) | 0.107 | 0.204 | 0.019 |
IL-1 (pg/ml) | -0.123 | -0.030 | -0.120 |
IL-6 (pg/ml) | 0.248 | 0.298* | 0.359** |
Drug therapy | Â | Â | Â |
Current prednisone dose (mg/day) | 0.156 | 0.152 | 0.279 |
Cumulative prednisone dose (mg) | 0.042 | 0.008 | 0.071 |
Cumulative pulsed MP (mg) | -0.051 | -0.155 | -0.096 |
Metabolic syndrome | Â | Â | Â |
Waist circumference (cm) | 0.036 | 0.249 | 0.127 |
SBP (mmHg) | 0.159 | 0.011 | 0.019 |
DBP (mmHg) | -0.042 | -0.073 | -0.097 |
HDL-cholesterol (mmol/l) | -0.093 | -0.103 | -0.091 |
Triglycerides (mmol/l) | 0.186 | 0.181 | 0.079 |
QUICKI | -0.088 | -0.035 | -0.019 |
Uric acid (mmol/l) | 0.208 | 0.271 | 0.260 |
Others | Â | Â | Â |
Haemoglobin (g/dl) | -0.139 | -0.130 | -0.093 |
Leucocytes (× 106/l) | -0.017 | -0.096 | 0.199 |
Polymorphonuclear cells (×106/l) | 0.041 | -0.092 | 0.212 |
Platelets (109/l) | -0.025 | -0.142 | 0.104 |
Homocysteine (μmol/l) | 0.124 | 0.236 | 0.277 |
Thyrotropin (μIU/ml) | -0.132 | -0.007 | 0.020 |
LDL-cholesterol (mmol/l) | -0.139 | -0.078 | 0.175 |
Apolipoprotein(a) (mg/l) | 0.097 | 0.004 | 0.063 |
GFR (ml/min) | -0.285* | -0.144 | -0.121 |
Urinary albumin/creatinine (mg/mmol) | -0.182 | -0.163 | -0.031 |