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Table 3 Spearman correlations among biomarkers and potential cardiovascular risk factors

From: Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis

Cardiovascular risk factor VCAM-1 (pg/ml) ICAM-1 (pg/ml) ELAM-1 (pg/ml)
Demographic    
Age (years) 0.279 0.149 0.148
Lifestyle    
Smoking (cigarettes/day) 0.209 0.253 0.062
Alcohol (units/week) 0.209 0.112 -0.072
Exercise (hours/week) 0.034 0.085 -0.055
Systemic inflammation    
hs-CRP (mg/l) 0.289 0.189 0.217
ESR (mm/hour) 0.217 0.175 0.195
Disease duration (years) 0.138 0.069 0.079
Disease severity    
Radiographic score 0.157 -0.012 0.092
Rheumatoid factor (IU/ml) 0.319** 0.363** 0.290
Cytokines    
TNF-α (pg/ml) 0.107 0.204 0.019
IL-1 (pg/ml) -0.123 -0.030 -0.120
IL-6 (pg/ml) 0.248 0.298* 0.359**
Drug therapy    
Current prednisone dose (mg/day) 0.156 0.152 0.279
Cumulative prednisone dose (mg) 0.042 0.008 0.071
Cumulative pulsed MP (mg) -0.051 -0.155 -0.096
Metabolic syndrome    
Waist circumference (cm) 0.036 0.249 0.127
SBP (mmHg) 0.159 0.011 0.019
DBP (mmHg) -0.042 -0.073 -0.097
HDL-cholesterol (mmol/l) -0.093 -0.103 -0.091
Triglycerides (mmol/l) 0.186 0.181 0.079
QUICKI -0.088 -0.035 -0.019
Uric acid (mmol/l) 0.208 0.271 0.260
Others    
Haemoglobin (g/dl) -0.139 -0.130 -0.093
Leucocytes (× 106/l) -0.017 -0.096 0.199
Polymorphonuclear cells (×106/l) 0.041 -0.092 0.212
Platelets (109/l) -0.025 -0.142 0.104
Homocysteine (μmol/l) 0.124 0.236 0.277
Thyrotropin (μIU/ml) -0.132 -0.007 0.020
LDL-cholesterol (mmol/l) -0.139 -0.078 0.175
Apolipoprotein(a) (mg/l) 0.097 0.004 0.063
GFR (ml/min) -0.285* -0.144 -0.121
Urinary albumin/creatinine (mg/mmol) -0.182 -0.163 -0.031
  1. DBP, diastolic blood pressure; ELAM, endothelial leukocyte adhesion molecule; ESR, erythrocyte sedimentation rate; GFR, glomerular filtration rate; HDL, high-density lipoprotein; hs-CRP, high-sensitivity C-reactive protein; ICAM, intercellular adhesion molecule; IL, interleukin; LDL, low-density lipoprotein; MP, methylprednisolone; QUICKI, Quantitative Insulin Sensitivity Check Index; SBP, systolic blood pressure; TNF, tumour necrosis factor; VCAM, vascular adhesion molecule. *P ≤ 0.01; **P < 0.006.