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Table 3 Autoantibodies as prognostic markers of poor outcomes

From: Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritis

Autoantibody Measure Outcomes at 30 months
   Persistence RA criteria Severity
RF Sensitivity 47.2 57.1 55.4
  Specificity 91.7 62.8 63.0
  Positive LR 5.69 1.53 1.50
Anti-Sa Sensitivity 34.4 39.3 44.6
  Specificity 95.8 72.7 79.3
  Positive LR 8.26 1.44 2.16
Anti-CCP Sensitivity 39.2 39.3 42.9
  Specificity 91.7 66.9 70.7
  Positive LR 4.70 1.19 1.46
  1. Combinations of antibodies (rheumatoid factor (RF) and/or anti-Sa and/or anti-cyclic citrullinated peptide (anti-CCP)) are not shown, because none brought any improvement over the detection of anti-Sa alone. LR, likelihood ratio; RA, rheumatoid arthritis.