Table 3 Skin infections in patients with rheumatoid arthritis (RA) given TNF-α-blocking therapy
Time to event | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Infection | No. of events | Median | Range | Druga (no.) | Active treatmentb (no.) | Rechallenge (no.) | Permanent withdrawal of anti-TNF-αc (no.) | Biopsy (no.) | Cultured species |
Fungal | 20 | 8.7 | 1.1–61.1 | ||||||
Dermatomycosis | 9 | A 3, I 4, E 2 | 7 | 0 | 1 | Trichophyton verrucosum (1) T. rubrum (1) | |||
Onychomycosis | 3 | A 3 | 3 | 0 | 0 | ||||
Combination | 5 | A 3, I 1, L 1 | 4 | 0 | 1 | Trichophyton rubrum (3) T. mentagrofytes (1) | |||
Candidiasis | 3 | I 3 | 2 | 0 | 0 | Candida spp. (2) | |||
Bacterial | 11 | 9.5 | 1.4–52.5 | ||||||
Folliculitis | 5 | A 3, E 2 | 4 | yes, negative | 1 | 2 | Staphylococcus aureus (1) | ||
Erysipelas | 3 | E 2, I 1 | 3 | yes, negative | 2 | 1 | |||
Bacterial superinfection of eczema | 2 | A 1, I 1 | 1 | yes, positive | 1 | 0 | |||
Furuncle | 1 | I 1 | 0 | 0 | 0 | ||||
Viral – herpes zoster | 2 | 17.3, 40.9d | A 1, I 1 | 0 | 0 | 0 | |||