Table 5 Other dermatological events in patients with rheumatoid arthritis (RA) given TNF-α-blocking therapy
Patient no. | Age (yr) | Sex | Diagnosis | Druga | Active treatment | Event | Clinical description | Localization | Time to event | Biopsy | Comedicationb | Permanent withdrawal anti-TNF-α | Therapy | Course |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 56 | f | RA | A | Yes | Lymphomatoid papulosis-like eruption | Macular erythematosquamous lesions | Lower arms, upper legs and trunk | 2.6 | Yes | naproxen | No | None | Recovery |
2 | 53 | f | RA | A | Yes | Rosacea | Diffuse erythema, scaling, telangiectasias | Head and face | 1.9 | Yes | prednisolone, captopril, indomethacin, midazolam | No | Topical | Persisting |
3 | 74 | f | RA | E | Yes | Pruritus | Itch | Trunk | 2.5 | No | None | No | Topical | Unknown |
4 | 61 | f | RA | I | No | Ecchymoses | Ecchymoses | Hands and feet | 25.9 | No | AZA, prednisolone | No | Topical | Partial recovery |
5 | 58 | f | RA | I | Yes | Drug-induced systemic lupus emythematosus | Discoid erythematous lesions, aphthous lesions, ANA positive, anti-ds-DNA positive | Hands, face, scalp | 20.0 | No | MTX | Yes | Topical and systemic | Recovery, no rechallenge |
6 | 68 | m | RA | I | Yes | Transient swelling of unknown cause | Transient swelling 2 × 3 cm | Scalp | 20.0 | No | MTX, folic acid, naproxen | No | None | Recovery |
7 | 52 | f | RA | L | Yes | Dermatomyositis | Livid erythema, raised CPK, decreased proximal muscular strength | Inner upper arms and legs | 2.5 | Yes | None | Yes | None | Recovery |
8 | 53 | m | RA | L | No | Erythema nodosum | Painful erythematous nodules | Lower legs | 7.4 | Yes | AZA, naproxen, paracetamol | No | Topical | Partial recovery |