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Table 2 Comparison of the overall mutational frequencies of VH rearrangements obtained from individual peripheral CD19+ (CD27- or CD27+) B cells of rheumatoid arthritis patient A before therapy and 7 months after first therapy

From: Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody

 

Before therapy

7 months after therapy

 

n

Mutations (n)

Total bp

Mutational frequency (%)

n

Mutations (n)

Total bp

Mutational frequency (%)

CD19+CD27-

18

27

4,349

0.62

15

183

3,443

5.31*

CD19+CD27+

Not determined

22

477

5,745

8.30

  1. * P < 0.0001 versus before therapy using chi-square test.