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Figure 4 | Arthritis Research & Therapy

Figure 4

From: The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration

Figure 4

Effect of IL-1 on MMP and ADAMTS gene expression in cells from human intervertebral discs. Relative gene expression was normalized to that of the GAPDH (glyceraldehyde-3-phosphate dehydrogenase) housekeeping gene and untreated controls (hence control is graphed at 1 on the log scale) for matrix metalloproteinase (MMP)-3 (a), MMP-13 (b), ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-4 (c), and ADAMTS-5 (d) following IL-1β treatment of cells from two regions of non-degenerate (non-deg) (n = 6) and degenerate (n = 24) discs. **P < 0.05. AF, annulus fibrosus; NP, nucleus pulposus.

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