Figure 5
From: The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration
Effect of IL-1 treatment on matrix gene expression in cells from human intervertebral discs. Relative gene expression was normalized to the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) housekeeping gene and untreated controls (hence control is graphed at 1 on the log scale) for SOX6 (a), SOX9 (b), collagen type I (c), collagen type II (d), and aggrecan (e) following IL-1β treatment of disc cells from two regions of non-degenerate (non-deg) (n = 6) and degenerate (n = 24) discs. **P < 0.05. AF, annulus fibrosus; NP, nucleus pulposus.