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Table 3 Comparison of the expression of selected genes in two groups of patients with rheumatoid arthritisa

From: Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specimens

Candidate gene

Group Ib

Group IIb

Q (%)

P c

A – Expressed at higher levels in group II than in group I

   CASP9

-0.029 ± 0.018

0.020 ± 0.014

0.25

<0.001

   PIG11

-0.025 ± 0.021

0.024 ± 0.017

0.25

<0.001

   CTSG

-0.018 ± 0.024

0.031 ± 0.021

0.25

0.001

   CSF2RB

-0.020 ± 0.024

0.019 ± 0.021

0.61

0.006

   TNFRSF1A

-0.023 ± 0.029

0.015 ± 0.016

0.77

0.010

   IL10RB

-0.021 ± 0.027

0.017 ± 0.021

0.90

0.012

B – Expressed at higher levels in group I than in group II

   FN1

0.023 ± 0.018

-0.030 ± 0.019

0.25

<0.001

   B2M

0.020 ± 0.023

-0.028 ± 0.022

0.25

0.001

   SDC2

0.023 ± 0.024

-0.024 ± 0.021

0.25

0.001

   CTSB

0.006 ± 0.019

-0.036 ± 0.026

0.84

0.002

   STAT1

0.021 ± 0.031

-0.020 ± 0.014

1.19

0.008

   ITGB2

0.021 ± 0.025

-0.018 ± 0.023

1.51

0.008

   IFNGR2

0.019 ± 0.026

-0.016 ± 0.026

3.28

0.022

  1. aStatistical analysis on microarray data was performed using the significance analysis of microarrays (SAM) method (see Materials and methods). Q, which is the lowest false discovery rate, was considered significant at less than 5%. It is similar to the familiar P value, but adapted to the analysis of a large number of genes. bMeans ± standard deviations for the group, using log-transformed and median-centered microarray data. cValues calculated by t-test. P <0.05 was considered significant.