Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes

Table 3 Nuclear mutational burden data of OA and RA patient tissue and cultured fibroblasts

Patients	Nucleotides sequenced	Number of total mutations	Total mutational burden (mutations/kbp)	Number of amino acid changes	Expressed mutational burden (mutations/kbp)	OA vs RA^a
Fibroblasts
OA	10971	36	3.281	24	2.188
RA	7317	15	2.050	10	1.367	ρ = 0.2
Tissue
OA	18287	32	1.750	15	0.820
RA	24522	41	1.672	21	0.856	ρ = 0.2

^aTwo-tailed Fisher's exact test. kbp, kilobase pairs; OA, osteoarthritis; RA, rheumatoid arthritis.

ISSN: 1478-6362