Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes

Table 4 Predicted epitopes for HLA DRB10101 and HLA DRB10401 which were changed by nonsynonymous mutations

Patient	Amino acid start position	Predicted core epitope (before mutation)	Predicted -logIC₅₀ (M)	New epitope with amino acid change^a	New predicted -logIC₅₀ (M)
HLA DRβ*0101
RA313	274	RTAYPRFRY	6.661	RTAHPRFRY	6.896
RA307	99	NLGLLFILA	6.51	SLGLLFILA	6.549
OA302	215	YAAGPFALF	6.681	YAAGPFALS	5.708
HLA DRβ*0401
RA307	259	FVTKTLLLT	7.329	FVAKTLLLT	7.316
RA313	88	PLPMPNPLV	7.093	PLPIPNPLV	6.946
RA307	93	NPLVNLNLG	7.09	NPLVNLSLG	7.148

^aBold indicates amino acid changed by mutation; a -logIC₅₀ value above 6.5 is considered to be a binder for prediction purposes. IC₅₀, median inhibitory concentration.

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