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Table 1 Serological markers of inflammation and histopathological findings were not significantly affected by ovariectomy

From: Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation

Arthritis OVX No. of mice IgG (mg/ml) CII antibody (ng/ml) Interleukin-6 (pg/ml) Frequency of arthritis, day 45 (%) Arthritic score, day 45 Histopathology (score)
- - 10 10 (10–12) n.d 62 (48–67) 0 0 0
  + 10 10 (7–15) n.d 80 (42–111) 0 0 0
+ - 18 18 (15–23) 4.6 (2.6–8.0) 343 (214–755) 100 8 (7–10)*** 9.5 (7.0–11.5)
  + 15 18 (15–18) 3.5 (2.3–4.6) 371 (280–602) 100 11 (10–12) 11.0 (8.9–13.0)
  1. Values are medians and interquartile ranges for each group. The maximum arthritic score was 12 points per mouse. ***P < 0.001 between sham-operated and ovariectomized arthritic mice. CII, type II collagen; n.d., not detectable; OVX, ovariectomy.