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Table 1 Summary of adhesion molecules and chemokines/cytokines differentially expressed in CIA joints at early stages of disease and their GO terms.

From: Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis

Affymetrix ID Change Gene ID Description Go Term/Function
Solely changed in comparison CFA/collagen II versus CFA
   1423760_at Up Cd44 CD44 antigen GO:0007155 cell adhesion
Solely changed in comparison CFA/collagen II versus no treatment
   1422103_a_at Dn Stat5b Signal transducer and activator of transcription 5B GO:0030155 cell adhesion
   1423166_at - Dn Cd36 CD36 antigen GO:0007155 cell adhesion
   1427165_at - Up Il13ra1 IL-13 receptor alpha 1 GO:0004907 IL activity
   1434044_at - Dn Repin1 Replication initiator 1 GO:0006954 inflammatory response
   1452483_a_at Up Cd44 CD44 antigen GO:0007155 cell adhesion
   1452514_a_at Dn Kit Kit oncogene GO:0006935 chemotaxis
Solely changed in comparison CFA versus no treatment
   1416156_at Dn Vcl Vinculin GO:0005912 adherens junction
   1417705_at Dn Otub1 OTU domain, ubiquitin aldehyde binding 1 GO:0006955 immune response
   1422873_at Dn Prg2 Proteoglycan 2, bone marrow GO:0006955 immune response
   1430375_a_at Up Ccl27 Chemokine (CC motif) ligand 27 GO:0008009 chemokine activity
   1437807_x_at Dn Catna1 Catenin α1 GO:0005912 adherens junction
   1452020_a_at Up Siva CD27 binding protein GO:0005175 CD27 receptor binding
   1455158_at Dn Itga3 Integrin α3 GO:0007155 cell adhesion
Changed in comparisons CFA/collagen II vs. CFA and CFA vs. no treatment
   1450488_at Dn-Up Ccl24 Chemokine (CC motif) ligand 24 GO:0008009 chemokine activity
Changed in comparisons CFA/collagen II vs. no treatment and CFA vs. no treatment
   1419329_at Dn Dn Sh3d4 SH3 domain protein 4 GO:0007155 cell adhesion
   1420465_s_at Up Up Mup1 Major urinary protein 1 GO:0016068 type I hypersensitivity
   1420553_x_at Dn Dn Serpina1a Serine proteinase inhibitor, clade A, member 1a GO:0006953 acute-phase response
   1423017_a_at Up Up Il1rn IL-1 receptor antagonist GO:0006955 immune response
   1423734_at Up Up Rac1 RAS-related C3 botulinum substrate 1 GO:0007155 cell adhesion
     GO:0006954 inflammatory response
   1423885_at Dn Dn Lamc1 Laminin γ1 GO:0007155 cell adhesion
   1427164_at Up Up Il13ra1 IL-13 receptor α1 GO:0004907 IL activity
   1435148_at Dn Dn Atp1b2 ATPase, Na+/K+ transporting, β2 polypeptide GO:0007155 cell adhesion
   1448303_at Dn Dn Gpnmb Glycoprotein nmb GO:0007155 cell adhesion
   1451767_at Up Up Ncf1 Neutrophil cytosolic factor 1 GO:0006954 inflammatory response
  1. Shown are differentially expressed genes associated with adhesion or inflammation with respect to Gene Ontology (GO) terms. The genes are a subset of those shown in the Venn diagram (Fig. 1). The first column gives the probe set identification number (ID) of the Affymetrix chip Moe430a. The second column lists whether the gene is significantly upregulated (Up) or downregulated (Dn; minimum 1.5-fold) in a particular comparison, ordered complete Freund's adjuvant (CFA)/collagen II versus CFA, CFA/collagen II versus no treatment, and CFA versus no treatment. Columns three to five show the gene symbol, its name and GO terms. For further details, see Materials and method. IL, interleukin.