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Table 2 Summary of disease-related data of perforin-deficient (pfp-/-) mice compared with pfp+/- and pfp+/+ mice

From: Perforin deficiency attenuates collagen-induced arthritis

Genotype (n) Day of onset Incidence (%) Severity Maxscore AUC
    Day 50 Day 75 Day 82   
Pfp-/- (13) 59 ± 4.9 54 0.9 ± 0.8 2.1 ± 1.6 3.0 ± 1.5a 3.4 ± 1.4b 31.9 ± 23.0c
Pfp+/- (14) 52 ± 3.5 64 1.4 ± 0.6 3.8 ± 0.9 4.0 ± 0.9a 5.6 ± 1.2b 44.6 ± 12.3c
Pfp+/+ (14) 53 ± 3.6 64 1.3 ± 0.4 5.2 ± 1.2 5.6 ± 0.9a 7.3 ± 1.1b 59.4 ± 16.7
  1. Evaluations and analyses were performed as described in Materials and methods. Maxscore was calculated as the mean of the maximum score value for each individual mouse of a given genotype. Data are group mean values ± SEM. Values with the same superscript letter are significantly different (P < 0.05). AUC, area under the curve.