Perforin deficiency attenuates collagen-induced arthritis

Table 2 Summary of disease-related data of perforin-deficient (pfp^-/-) mice compared with pfp^+/- and pfp^+/+ mice

Genotype (n)	Day of onset	Incidence (%)	Severity			Maxscore	AUC
			Day 50	Day 75	Day 82
Pfp^-/- (13)	59 ± 4.9	54	0.9 ± 0.8	2.1 ± 1.6	3.0 ± 1.5^a	3.4 ± 1.4^b	31.9 ± 23.0^c
Pfp^+/- (14)	52 ± 3.5	64	1.4 ± 0.6	3.8 ± 0.9	4.0 ± 0.9^a	5.6 ± 1.2^b	44.6 ± 12.3^c
Pfp^+/+ (14)	53 ± 3.6	64	1.3 ± 0.4	5.2 ± 1.2	5.6 ± 0.9^a	7.3 ± 1.1^b	59.4 ± 16.7

Evaluations and analyses were performed as described in Materials and methods. Maxscore was calculated as the mean of the maximum score value for each individual mouse of a given genotype. Data are group mean values ± SEM. Values with the same superscript letter are significantly different (P < 0.05). AUC, area under the curve.

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