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Figure 10 | Arthritis Research & Therapy

Figure 10

From: NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis

Figure 10

Possible involvement of NADPH oxidase in mediating cartilage destruction during ICA. Immune complexes (ICs) bind to FcγRI and FcγRIII expressed on macrophages, and cause the activation of NADPH oxidase. IFN-γ strongly elevates the expression of mainly FcγRI and NADPH oxidase. Oxygen radical production causes chondrocyte (CH) death and the activation of matrix metalloproteinases (MMP), leading to matrix degradation in the cartilage expressed as VDIPEN epitopes.

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Arthritis Research & Therapy

ISSN: 1478-6362

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