Figure 3

Differences in the loss of proteoglycan and chondrocyte between cultures incubated with different mABs. (a) Loss of toluidine blue staining between cultures incubated with CIIF4 (white) and cultures incubated with CIIC1 (light grey) and M2139 (dark grey) over the course of 21 days. (b) The number of empty chondrons expressed as a percentage of the total number of chondrons, indicating the loss of chondrocyte from the extracellular matrix. The columns represent the mean of each measurement and error bars indicate 1 standard deviation. The asterix represents p < 0.05.