From: Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis
 | Anti-CCP-negative (n = 228) | Anti-CCP-positive (n = 226) |
---|---|---|
Female [n (%)] | 147 (64%) | 150 (66%) |
Age at inclusion (mean ± standard deviation) | 57 ± 17 | 55 ± 16 |
Morning stiffness | Â | Â |
   No [n (%)] | 30 (13%) | 30 (13%) |
   Yes (min) (mean ± standard deviation) | 118 ± 138 | 123 ± 128 |
Type of initial joint symptoms [n (%)]a | Â | Â |
   Pain | 208 (91%) | 205 (91%) |
   Swelling | 146 (64%) | 135 (60%) |
   Stiffness | 106 (46%) | 85 (38%) |
   Function loss | 64 (28%) | 57 (25%) |
   Redness or increased surface temperature of joints | 19 (8%) | 26 (12%) |
Localization of initial joint symptoms [n (%)] | Â | Â |
   Small joints of hands and/or feet | 105 (46%) | 112 (50%) |
   Large joints | 54 (24%) | 50 (22%) |
   Both small and large joints | 63 (28%) | 59 (26%) |
   Unknown | 6 (2%) | 5 (2%) |
Localization of initial joint symptoms [n (%)] | Â | Â |
   Upper limbs | 114 (50%) | 86 (38%)* |
   Lower limbs | 72 (32%) | 77 (34%) |
   Both upper and lower limbs | 25 (11%) | 45 (20%)* |
   Unknown | 18 (8%) | 18 (8%) |
Localization of initial joint symptoms [n (%)] | Â | Â |
   Symmetric | 145 (64%) | 130 (58%) |
   Asymmetric | 71 (31%) | 83 (37%) |
   Unknown | 10 (4%) | 13 (6%) |
VAS patients' rated global disease activity (0–100) | 51.3 ± 39.9 | 46.7 ± 28.2 |
HAQ score (mean ± standard deviation) | 1.0 ± 0.7 | 1.0 ± 0.7 |