Percentage survival over time of mice given implants of CHO cells producing recombinant human IgG. This Kaplan–Meier plot shows the percentage of mice in each group that were still alive at each time point in the second experiment. The curves are significantly different by the log-rank test (P = 0.0001). There was reduced survival of mice in the groups that were given implants of Chinese hamster ovary (CHO) cells producing B3 and B3(R27aS), as compared with those mice in groups that were given CHO cells containing the empty vector or that were only primed with pristane. The mice were killed when they became ill; there was no evidence of ascites growth in any of these mice.