Incidence of CIA in E-selectin mutant, E/P-selectin mutant, and wild-type mice. E-selectin mutant (n = 56), E/P-selectin mutant (n = 54), and wild-type mice (n = 48) were immunized with chick type II collagen and assessed for the development of arthritis for 90 days by a blinded observer. The results are presented as the mean of three separate CIA experiments. The cumulative number of mice in each group is given as a percentage. CIA, collagen-immunized arthritis; wt, wild-type.