Arthritis severity in E-selectin mutant, E/P-selectin mutant, and wild-type mice. Arthritic paws were evaluated for the severity of inflammation and the presence of distortion and ankylosis as described in the Materials and method section. Daily severity scores were calculated from the combined inflammation, distortion, and ankylosis scores. Data are shown from three separate CIA experiments, and the mean arthritis severity is shown for each genotype. P < 0.05 for both E-selectin and E/P-selectin mutant versus wild type mice. wt, wild-type.