Figure 3
From: Accelerated development of arthritis in mice lacking endothelial selectins
Cytokine expression in joint homogenates collected from pre-onset CIA mice. (a) Collagen-immunized E/P-selectin mutant mice exhibit increased MIP-1α and IL-1β in joint homogenates compared with immunized wild-type mice. (b) Joints from E-/P-selectin mutant mice during the early stages of arthritis show increased IL-1β expression compared with wild-type mice. (c) Chronic (day 80 collagen-immunized) E/P-selectin mutant mice show elevated levels of IL-1β and MIP-1α in their joint tissues compared with wild-type mice. Values are expressed as mean ± standard error of the mean. *P < 0.05. CIA, collagen-immunized arthritis; MIP, macrophage inflammatory protein; n, number of joints; wt, wild-type.