Figure 5
From: Accelerated development of arthritis in mice lacking endothelial selectins
IL-1β expression in serum and joint tissue from non-collagen-immunized mice. (a) IL-1β was significantly elevated in serum from nonimmunized E/P-selectin mutant compared with nonimmunized wild-type mice. Serum from E/P-selectin mutant mice kept on antibiotics for 2 weeks also had elevated serum IL-1β levels, indicating that the basal overexpression of IL-1β in nonimmunized E/P-selectin mutant mice is not due to bacterial infections. (b) IL-1β was also significantly increased in joint homogenates from nonimmunized E/P-selectin mutant compared with nonimmunized wild-type mice. Values are expressed as mean ± standard error of the mean. *P < 0.05. n, number of mice (panel (a) or number of joints (or mice for serum; panel (b); wt, wild-type.