|
DAS cut-off
|
Sensitivity
|
Specificity
|
PPV
|
NPV
|
Accuracy
|
|---|
|
2.0
|
0.99
|
0.13
|
0.23
|
0.98
|
0.31
|
|
2.5
|
0.99
|
0.22
|
0.25
|
0.99
|
0.38
|
|
2.6
|
0.99
|
0.26
|
0.26
|
0.99
|
0.41
|
|
3.0
|
0.98
|
0.38
|
0.29
|
0.98
|
0.50
|
|
3.2
|
0.96
|
0.46
|
0.32
|
0.98
|
0.57
|
|
4.0
|
0.79
|
0.66
|
0.38
|
0.92
|
0.68
|
|
4.5
|
0.76
|
0.77
|
0.47
|
0.92
|
0.77
|
|
5.0
|
0.58
|
0.87
|
0.55
|
0.89
|
0.81
|
|
5.1
|
0.53
|
0.88
|
0.55
|
0.88
|
0.81
|
|
5.5
|
0.43
|
0.95
|
0.69
|
0.86
|
0.84
|
|
6.0
|
0.34
|
0.97
|
0.73
|
0.85
|
0.83
|
|
6.5
|
0.19
|
0.98
|
0.72
|
0.82
|
0.81
|
- DAS, disease activity score; PPV, positive predictive value (predictive value to give a dose increase as a measure of insufficient response); NPV, negative predictive value (predictive value to continue on the current dose as a measure of good response); PPV, NPV and accuracy were calculated using the following formulae:
-
-
- c) Accuracy = sensitivity* a_priori_chance + specificity* (1-a_priori_chance)
- The a priori chance is given by the percentage of patients that need a dose increase as a measure of insufficient response.
