Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides

Table 1 Characteristics of the PR3/MPO-ANCA-positive patients with idiopathic and antithyroid DIDs

	Patients with idiopathic vasculitides (n = 56)	Patients with antithyroid DIDs (n = 16)
Female sex, n (%)	29 (52)	15 (94)*
Age, years	52.8 ± 10.9	31 ± 9.8**
Range	18–72	20–52
Months between first complaints and ANCA detection	3.8 ± 1.2	2.3 ± 1.1**
Graves' disease/Hashimoto thyroiditis, n	0	13/3
Propylthiouracil/methimazole, n	0	12/4

Values represent either numbers of patients (%) or mean ± standard deviation. *p < 0.01, **p < 0.001. ANCA, antineutrophil cytoplasmic antibodies; DID, drug-induced autoimmune disease; MPO, myeloperoxidase; PR3, proteinase 3.

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