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Table 2 Initial clinical manifestations in PR3/MPO-ANCA-positive patients with idiopathic vasculitides and antithyroid DIDs

From: Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides

 

Patients with idiopathic vasculitides (n = 56)

Patients with antithyroid DIDs (n = 16)

Systemic

56 (100)

16 (100)

   Arthralgia/myalgia

56(100)

16 (100)

   Fever >38.5°C

48 (86)

4 (25)***

   Weight loss >2 kg a month

47 (84)

5 (31)***

Renal

42 (75)

3 (19)***

   Acute renal failure

25 (45)

1(6)**

   Proteinuria, hematuria

17 (30)

2 (12)

Lung

28 (50)

3 (19)*

   Infiltrate

15 (27)

2 (12)

   Nodules

10 (18)

1 (6)

   hemoptysis

14 (25)

1 (6)

Pulmonary-renal syndrome

22 (39)

1 (6)*

Skin

14 (25)

10 (62.5)**

   Necrosis

11(20)

2 (12)

   Gangrene

3 (5)

0

   Purpura

5 (9)

1 (6)

   Urticaria-like vasculitis

0

5 (31) ***

   Urticaria

0

2 (12.5)*

Gastrointestinal tract

7 (12)

0

Ear, nose

15 (27)

0*

Eyes

7 (12)

0

Nervous system

26 (46)

1 (6)**

   Central

13 (20)

0

   Peripheral

15 (27)

1 (6)

  1. All values represent numbers of patients (%). *p < 0.05 **p < 0.01 ***p < 0.001. ANCA, antineutrophil cytoplasmic antibodies; DID, drug-induced autoimmune disease; MPO, myeloperoxidase; PR3, proteinase 3.