| NSAID alone | NSAID + PPI | COX-2 | COX-2 + PPI |
---|---|---|---|---|
Appropriate | Age <65 years, no aspirin and no previous gastrointestinal event | On aspirin Previous gastrointestinal event | On aspirin and no previous gastrointestinal event Not on aspirin and previous gastrointestinal event | Previous gastrointestinal event and on aspirin On aspirin and steroids/warfarin |
Inappropriate | Previous gastrointestinal event On aspirin, steroids, or warfarin | Age <65 years, not on aspirin and no previous gastrointestinal event | - | Not on aspirin and no previous gastrointestinal event Age <65 years, on aspirin but no previous gastrointestinal event Age <65 years, previous uncomplicated gastrointestinal event and not on aspirin, steroids, or warfarin |