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Table 1 Recommendations for the treatment of NSAID related dyspepsia and mucosal injury

From: Practical approaches to minimizing gastrointestinal and cardiovascular safety concerns with COX-2 inhibitors and NSAIDs

Clinical situation

Recommendation

Dyspepsia

Empirical treatment with H2 receptor antagonist or PPI; individualize therapy

Helicobacter pylori infection

Treatment to eradicate infection in patients with a history of peptic ulcer; PPI therapy

Active gastroduodenal ulcer

 

   NSAID discontinued

Treatment with H2 receptor antagonist or a PPI

   NSAID continued

Treatment with a PPI

Prophylactic therapy

Treatment with a PPI or misoprostol or a COX-2 (preferential) or selective NSAID

  1. COX, cyclo-oxygenase; NSAID, nonsteroidal anti-inflammatory drug; PPI, proton pump inhibitor. Adapted, with permission, from [6]. Copyright © 1999 Massachusetts Medical Society. All rights reserved.
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Arthritis Research & Therapy

ISSN: 1478-6362

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