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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen

Figure 3

Antibody response to C1 and U1 and correlations between arthritis severity and anti-epitope response. (a) Mean antibody responses measured in sera against the C1 triple-helical peptide over time in control (open circles, n = 5), healthy (open triangles, n = 10) and arthritic (open squares, n = 15) mice. (b) Analysis of the correlation between the mean arthritis score and the anti-C1 response during the disease course. Each point represents the correlation coefficient, r. The values of r are significant on days 37, 42, 78, 92, 106 to 113 and 120 to 156 and range from P ≤ 0.05 to P ≤ 0.0001. (c) Mean antibody responses measured in sera against the U1 triple-helical peptide over time in control (open circles, n = 5), healthy (open triangles, n = 10) and arthritic (open squares, n = 15) mice. (d) Analysis of the correlation between the mean arthritis score and the anti-U1 response during the disease course. Each point represents the correlation coefficient, r. The values of r are significant on days 32 to 92, 99 to 113 and 120 to 156.

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