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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen

Figure 4

Arthritis development in B10.Q(BALB/c×B10.Q)F2 mice and correlations between relapsing arthritis and responses to CII/CII-specific epitopes. (a) Arthritis course during 207 days of male and female B10.Q(BALB/c×B10.Q)F2 mice (8 to 12 weeks old) immunized with 100 μg of rat CII emulsified in incomplete Freund's adjuvant (IFA) on day 0 and boosted on day 35 with 50 μg of rat CII in IFA, showing the arthritis score of the diseased (n = 96, open squares) and healthy (n = 94, open circles) mice. Arrows indicate the bleeding time-points (days 35, 80 and 210). Results are means ± SEM. (b) Analysis of the correlation between the mean arthritis score and the anti-CII or anti-epitope responses during the disease course. Each point represents the correlation coefficient, r. The values of r are significant on day 35, 80 and 210 for CII, C1, J1 and U1. (c) Analysis of the correlation between the mean arthritis score and the anti-CII or anti-epitope responses related to mice with a relapsing disease, either on day 80 (n = 32) or on day 210 (n = 21). Each bar represents the correlation coefficient, r. The values of r are significant for the J1 epitope on day 80 and for the C1 epitope on day 210.

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