Possible therapeutic approaches against Synoviolin. Five approaches for Synoviolin regulation are described. (a,b) Regulation of the amount of Synoviolin by decoy oligonucleotides (a), anti-sense or RNA-mediated interference (b). (c) Inhibition of the signal(s) that activate Synoviolin enzyme activity. (d) Inhibition of the interaction between Synoviolin and its cofactors. (e) Inhibition of the interaction between Synoviolin and its substrates. siRNA, small interfering RNA.